Gut Bacteria Depression-Recent studies deliver strong evidence linking Depression and Gut Bacteria

Last Updated on December 22, 2022 by Dr Bucho

Gut Bacteria Depression: According to the Research, Study findings showed that a healthy gut microbiome transmits brain signals through the pathways involved in neurogenesis, neural transmission, microglial activation, and behavioral control under stable or stressful conditions.

Gut Bacteria Depression


Gut Bacteria Depression: With an average lifetime frequency of 11–15%, depression is one of the most prevalent mental illnesses in the world. During the COVID-19 pandemic, the prevalence has increased by a factor of two and even tripled in some nations. The mysterious pathophysiology of depression, however, makes it one of the most prevalent and poorly understood disorders. Treatment alternatives are ineffective; most antidepressants only marginally outperform placebo, and there are additional expenses associated with side effects, which can range from mild cognitive issues to even suicide.

The greatest proof to date that there is a connection between depression and gut flora comes from two recent research that were published in Nature Communications. The study does not prove that gut bacteria cause depression directly, but it does show a high association that may help develop new diagnostic biomarkers for mood conditions.

According to the Research, Study findings showed that a healthy gut microbiome transmits brain signals through the pathways involved in neurogenesis, neural transmission, microglial activation, and behavioral control under stable or stressful conditions. This process led several studies to recognize the importance of microbiomes in managing mental health issues Trusted Source

Around 3,000 participants in the HELIUS project from six different ethnicities were examined in the initial study, which was directed by academics from the University of Amsterdam (Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish, Moroccan). The unusual ethnic mix of the subjects allowed for the first examination of whether racial disparities affect the gut-mood relationship, even though the study’s main objective was to examine broad associations between the microbiome and Depression.

Regardless of ethnicity, the study generally discovered consistent links between general microbial diversity and sadness. In essence, the more diverse a person’s gut bacterial community was, the less probable it was that they would suffer from depression. Nature

Further, The other study focused more intently on the species of gut bacteria that may be connected to depression. During ongoing community health research being conducted in Rotterdam, the stools of roughly 1,000 people were carefully examined to look for links between particular bacteria and symptoms of depression. There was a direct correlation between 13 bacterial species and depressive symptoms. The Rotterdam Study is a population-based cohort study from the well-defined Ommoord district within Rotterdam, The Netherlands.

In this large study of 2593 individuals profiled for depressive symptoms and fecal microbiome, The Research team identified 12 genera and 1 microbial family associated with depressive symptoms. These include genera Sellimonas, Eggerthella, Ruminococcaceae (UCG002, UCG003, UCG005), Lachnoclostridium, Hungatella, Coprococcus, LachnospiraceaeUCG001, Ruminococcusgauvreauiigroup, Eubacterium ventriosum, Subdoligranulum and family Ruminococcaceae. Sellimonas, Eggerthella, Lachnoclostridium and Hungatella were more abundant in individuals with higher depressive symptoms.

Also Read: Covid-19: New X-ray technology Developed at TUM, May Improve The Diagnosis of Covid-19.

Dr Najaf Amin, co-corresponding author and Senior Research Associate at Oxford Population Health, said ‘The prevalence of depression, which has increased significantly as a result of the COVID-19 pandemic, and the devastating effect it can have on people’s lives has created a pressing need to improve our limited understanding of it. The results of this study provide new grounds for research into how changing the gut microbiome through diet could reduce the symptoms of depression, which could ultimately improve many people’s lives.’ OPH

Also Read: 5 Best Exercises after  C-Section For Speedy Recovery|C-section Exercises

Frequently Asked Questions

  1. How gut bacteria affects your mood?

    According to Recent studies at the University of Amsterdam, Gut bacteria create a variety of neurotransmitters, such as dopamine, norepinephrine, and gamma-aminobutyric acid, that can influence how we feel. These molecules are crucial in producing strong emotions of pleasure, reward, or anxiety.

  2. What foods are good for gut bacteria?

    You should consult your Health Care Provider about it  while according to WebMD, Prebiotic foods (whole rains, bananas, greens, onions, garlic, soybeans, etc)  act as food for healthy gut bacteria. Probiotic foods like yogurt are full of good bacteria already.

  3. What gut bacteria is linked to depression?

    The intestinal bacterial strains Eggerthella, Subdoligranulum, Coprococcus and Ruminococcaceae have been reported to be associated with major depression in earlier studies

  4. Is my gut health making me depressed?

    Both a disturbed brain and a problematic intestine are capable of communicating with one another when they are both in distress. In this way, worry, stress, or depression can either induce or result in gastrointestinal or stomach discomfort in a person. This is due to the close relationship between the brain and the digestive system (GI).


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